Chronic pruritus is a common and challenging condition with limited effective treatment options. This prospective, randomized comparative study aimed to evaluate the short-term clinical efficacy and safety of acupuncture compared with narrow-band UVB phototherapy in patients with chronic generalized pruritus. A total of 90 adult patients were enrolled and treated for one month. Pruritus severity was assessed using the Visual Analogue Scale (VAS) and Investigator's Global Assessment (IGA) at baseline and after treatment.