Time-restricted Eating and Circadian Health in Night Shift Workers

The goal of this clinical trial is to learn about the effect of time-restricted eating (TRE) to 10 hours per day on glucose homeostasis, markers of the circadian system, homeostatic and hedonic regulation of appetite, and inflammation/oxidative stress status in night shift workers. The main questions it aims to answer are: 1) How does a time-restricted eating protocol affect glucose homeostasis in shift workers? and 2) How does a time-restricted eating protocol affect markers of the circadian system, homeostatic and hedonic regulation of appetite, and inflammation/oxidative stress status in shift workers? Participants will be asked to follow a TRE protocol on which they must restrict their eating to a self-selected time window of 10 hours a day, with mandatory fasting time between 24:00-06:00h. for 8 weeks. Researchers will compare the intervention with an additional period of 8 weeks, in which the participants will follow their usual diet without any time restriction, to see if the intervention improves glucose regulation appetite and markers of circadian system, homeostatic and hedonic regulation of appetite, and inflammation/oxidative stress.

NCT Number	NCT07451132
Lead Sponsor	University of Chile Collaborators: Agencia Nacional de Investigación y Desarrollo
Conditions	Intermittent Fasting in Shift-work
Enrollment	22 participants
Start Date	2023-10-30
Primary Completion	2025-07-11 (estimated)
Study Completion	2025-07-11 (estimated)
Updated on ClinicalTrials.gov	2026-05-13