Field Study on Intravenous Iloprost for Treatment of Severe Frostbite at High Altitude

The goal of this observational study is to learn whether intravenous iloprost treatment for severe frostbite (grades 3-4) is feasible and safe when delivered in pre-hospital, remote high-altitude settings. The main questions it aims to answer are: * Is it feasible to initiate and deliver guideline-based intravenous iloprost for grade 3-4 frostbite at high altitude and what logistical barriers arise? * Does field-based initiation of iloprost increase tissue preservation and reduce amputations (compared to historical cases from similar settings)? Participants receiving Iloprost as part of a frostbite treatment will be followed up after discharge as well as 6, 12 and 18 months to assess tissue preservation and long-term sequelae from the initial frostbite injury.

NCT Number	NCT07450469
Lead Sponsor	Institute of Mountain Emergency Medicine
Conditions	Frostbite, Altitude, Field Physician Care
Enrollment	10 participants
Start Date	2026-05
Primary Completion	2027-06 (estimated)
Study Completion	2028-05 (estimated)
Updated on ClinicalTrials.gov	2026-03-09