Clinical Trial

EBV-AST Cell Injection for EBV-Associated Lymphoproliferative Disorders

Recruiting Phase 1/2
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Summary
This is an investigator-initiated, open-label, single-arm, dose-escalation exploratory study to evaluate the safety, tolerability, and preliminary efficacy of EBV-AST cell injection in adults with EBV-associated lymphoproliferative disorders, including post-transplant lymphoproliferative disease (PTLD) and EBV-positive lymphomas. Participants will receive EBV-AST cell infusions intravenously every 2 weeks for up to 3 infusions at escalating dose levels. The primary objective is to assess safety and determine a potential optimal biologically active dose. Secondary objectives include preliminary tumor response and EBV-related virologic outcomes, as well as cellular PK/PD.
Trial Details
NCT Number NCT07450391
Lead Sponsor Daihong Liu
Conditions Epstein-Barr Virus-Associated Lymphoproliferative Disorders, EBV-Positive Lymphoma
Enrollment 18 participants
Start Date 2025-06-01
Primary Completion 2027-06-01 (estimated)
Study Completion 2027-06-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-04