Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial

The primary purpose of this study is to evaluate the efficacy and safety of Baricitinib combined with endovascular therapy in patients with acute anterior circulation large vessel occlusion, to address futile recanalization with priority, and to elucidating the mechanism of JAK/STAT pathway inhibition on neuroprotection and inflammatory regulation.

NCT Number	NCT07449910
Lead Sponsor	The First Affiliated Hospital of University of Science and Technology of China
Conditions	Acute Ichemic Stroke, Anterior Cerebral Artery Stroke, Baricitinib
Enrollment	750 participants
Start Date	2026-03-17
Primary Completion	2027-08-17 (estimated)
Study Completion	2028-01-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-04