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SPELHNCT07449832

Sperm Epigenome in Hodgkin Lymphoma

StatusRecruiting
PhaseNot applicable
Primary completion (estimated)

At risk: Primary completion moved at least 10 months later.

See at-risk trials from Rennes University Hospital

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Record History

All 3 versions: 3 with changes below. See every version on ClinicalTrials.gov ↗

  1. Primary and study completion pushed from Jan 1, 2030 to Nov 2030 Show 4 more changesShow less
    • Recruitment opened
    • Start date changed from estimate of Jun 1, 2026 to Nov 9, 2026
    • Eligibility criteria expanded, about 7 words
    • Site details revised
  2. Start date: Apr 1, 2026 to Jun 1, 2026
    • Primary completion pushed from Nov 1, 2029 to Jan 1, 2030
    • Study completion moved earlier from May 1, 2030 to Jan 1, 2030
    • Study description shortened, about 6 words
    v2
  3. Study First Submitted
  • Notable: the plan changed

Endpoints

Primary

Alterations in DNA methylation patterns in spermatozoa
Timeframe: Before chemotherapy, month 6, month 12, month 18, month 24 after chemotherapy
Alterations of histone 3 H3k4me3 retention sites in spermatozoa
Timeframe: Before chemotherapy, month 6, month 12, month 18, month 24 after chemotherapy

Secondary (2)

Spermogram exam
Identification of known environmental factors impacting spermatogenesis

Arms and interventions

Epigenetic analysis in semen samplesExperimental

30 men with hodgkin lymphoma will be followed during 24 months in order to search epigenetic modifications in male gametes

Other: Additional semen samples

Sites

1 site in 1 country

  • Centre Hospitalier Universitaire de RennesRennes, France