Losartan for Corneal Fibrosis

This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry, corneal aberrations and corneal scarring severity in adult patients with corneal scars of different etiologies. Participants will be randomly assigned to receive either topical losartan 0.8 mg/mL or placebo eyedrops 6 times per day for six months.

NCT Number	NCT07449000
Lead Sponsor	Universidad Autonoma de Nuevo Leon
Conditions	Corneal Scarring Fibrosis
Enrollment	46 participants
Start Date	2026-02-12
Primary Completion	2027-02-11 (estimated)
Study Completion	2027-03-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-08