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ACTG2/FLNA Testing Yield in Adult Idiopathic Chronic Intestinal Pseudo-Obstruction (CIPO) With Reduced/Absent Distal Esophageal Contractility

Study acronym: CIPO_GEN
StatusEnrolling by Invitation
PhaseNot specified
Started
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Record status
This record was last updated March 5, 2026 (before its estimated September 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Study title shortened, about 8 words
    • Eligibility criteria expanded, about 4 words
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
To assess the diagnostic yield of Sanger sequencing for ACTG2 and FLNA genes evaluation on blood or saliva sample in patients with idiopathic CIPO in which high-resolution esophageal manometry (HRM) shows reduced (DCI \<450 mmHg\*s\*cm) or absent distal esophageal contractility.
Trial Details
NCT Number NCT07448753
Lead Sponsor Marina Coletta
Collaborators: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Nottingham University Hospitals NHS Trust
Conditions
(from sponsor)		 Pseudo Obstruction
Related terms Intestinal Pseudo-Obstruction
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov