Colonic Delivery of DIM and Perilla Oil on Gut Hormones and Food Intake in Obesity

The goal of this clinical trial is to learn whether targeted food supplement capsules that release nutrients in the lower gut can increase appetite-regulating gut hormones and reduce food intake in adults with obesity. The main questions it aims to answer are: * Does the targeted supplement increase blood levels of appetite-related gut hormones such as PYY and GLP-1? * Does the supplement reduce calorie intake at a standardised test meal compared with placebo? Researchers will compare active supplement capsules with placebo capsules (inactive look-alike capsules) to see whether the supplement changes hormone levels and food intake. Participants will: * Attend two study visits after an overnight fast * Take supplement capsules or placebo capsules in random order * Provide repeated blood samples during each study visit * Complete hunger and appetite rating questionnaires * Eat standardised breakfast and lunch meals so that calorie intake can be measured

NCT Number	NCT07448519
Lead Sponsor	Queen Mary University of London
Conditions	Obesity & Overweight, Appetite Regulation
Enrollment	20 participants
Start Date	2023-06-13
Primary Completion	2023-08-02 (estimated)
Study Completion	2023-08-02 (estimated)
Updated on ClinicalTrials.gov	2026-03-24