The Impact of Dietary Salt on the Severity of Eczema

The goal of this clinical trial is to evaluate the feasibility of low-sodium diet to improve eczema severity. The main questions it aims to answer are: * Does a low-sodium diet improve eczema severity? * How does a low-sodium diet impact skin sodium concentration? * Is skin sodium concentration associated with eczema severity? Researchers will ask all participant to follow a low-sodium diet, then compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake. Participants will: * Follow a low-salt diet for the duration of the 24-week study * Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa * Complete up to 4 virtual check-in visits * Visit the clinic 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI

NCT Number	NCT07447063
Lead Sponsor	University of California, San Francisco Collaborators: United States Department of Defense
Conditions	Eczema, Atopic Dermatitis
Enrollment	40 participants
Start Date	2026-06-22
Primary Completion	2028-03-05 (estimated)
Study Completion	2028-05-05 (estimated)
Updated on ClinicalTrials.gov	2026-06-09