Clinical Trial

Comparative Analysis of Biotinylated, Irradiated and 51-Chromium Radiolabeled Red Blood Cells for Analysis of Recovery and Survival After Autologous Transfusion

Recruiting Phase 1
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Summary
This research is being done to compare the red blood circulation survival in healthy adult volunteers between the 51 chromium (51Cr) red blood cell (RBC) labeling method and the Biotin (BioRBC) red blood cell (RBC) labeling method to determine if biotinylated red blood cells (BioRBC) is an acceptable non radioactive alternative to 51 chromium (51Cr) radiolabeling for regulatory pharmacokinetic studies of red blood cell products.
Protocol Amendment History 1 change
critical Recruitment opened 2026-04-17
Trial Details
NCT Number NCT07446647
Lead Sponsor Jose Cancelas
Collaborators: Department of Health and Human Services
Conditions Healthy Volunteer Red Blood Cell Labeling Study; Not Disease Focused
Enrollment 20 participants
Start Date 2026-04-01
Primary Completion 2027-06-30 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-16