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Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training

Study acronym: PROTECT
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Eligibility criteria expanded, about 2 wordsv4 See this version in full on ClinicalTrials.gov ↗
  2. Secondary endpoints: 17 to 8v3 See this version in full on ClinicalTrials.gov ↗
  3. Start date: Jan 1, 2026 to Mar 9, 2026 Enrollment target: 126 to 120 · Secondary endpoints: 15 to 17 · Study description expanded, about 62 words · 1 morev2 Show 4 more changesShow less
    • Enrollment target: 126 to 120
    • Secondary endpoints: 15 to 17
    • Study description expanded, about 62 words
    • Eligibility criteria shortened, about 5 words

    See this version in full on ClinicalTrials.gov ↗

  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
McGill University
47 trials monitored
See 6 trials at risk
Stroke
3,289 trials monitored
See 141 trials at risk
The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these patients. Although physical exercise is usually recommended after stroke, there is very little information about the protective effect of exercise implemented in early stages of recovery as a potential protective measure against cognitive decline and dementia risk in these patients. This study will investigate the effect of a multimodal exercise intervention implemented early after the stroke event on cognition and on a selected group of markers that can predict cognitive decline and dementia risk.
Trial Details
NCT Number NCT07445841
Lead Sponsor McGill University
Collaborators: Jewish Rehabilitation Hospital, McMaster University, Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal, Montreal Neurological Institute and Hospital
Conditions Stroke
Enrollment 120 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov