Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training

The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these patients. Although physical exercise is usually recommended after stroke, there is very little information about the protective effect of exercise implemented in early stages of recovery as a potential protective measure against cognitive decline and dementia risk in these patients. This study will investigate the effect of a multimodal exercise intervention implemented early after the stroke event on cognition and on a selected group of markers that can predict cognitive decline and dementia risk.

NCT Number	NCT07445841
Lead Sponsor	McGill University Collaborators: Jewish Rehabilitation Hospital, McMaster University, Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal, Montreal Neurological Institute and Hospital
Conditions	Stroke
Enrollment	120 participants
Start Date	2026-03-09
Primary Completion	2030-01-30 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-06