Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia

This randomized, double-blind, sham-controlled trial compares three brain stimulation approaches-accelerated intermittent theta burst stimulation (aITBS), high-frequency repetitive transcranial magnetic stimulation (HF-rTMS), and sham stimulation-for treating cognitive deficits in treatment-resistant schizophrenia. Ninety patients receiving clozapine will be randomized 1:1:1 to receive 20 sessions over 4 weeks targeting the dorsolateral prefrontal cortex. The primary outcome is change in cognitive function measured by B-CATS score at 2, 4, and 12 weeks. Secondary outcomes include social cognition, symptom severity, brain metabolism (FDG-PET), and inflammatory biomarkers.

NCT Number	NCT07445620
Lead Sponsor	All India Institute of Medical Sciences, Bhubaneswar Collaborators: Indian Council of Medical Research
Conditions	Psychosis, Schizophrenia Disorder
Enrollment	90 participants
Start Date	2026-09-15
Primary Completion	2029-02-14 (estimated)
Study Completion	2029-12-14 (estimated)
Updated on ClinicalTrials.gov	2026-08-10