Clinical Trial

Home-Based Quadriceps Isometric Exercise for Knee Osteoarthritis Pain

Study acronym: KOA-ISO01
Completed
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Summary
Knee osteoarthritis is a common cause of pain and reduced mobility in older adults. Many people have limited access to supervised rehabilitation programs, highlighting the need for simple and safe home-based treatment options. This study evaluates whether a brief home-based quadriceps isometric exercise program can reduce knee pain in community-dwelling older adults. Participants perform short daily muscle contractions of the thigh muscles for 28 days. In addition, participants are assigned to receive one of four topical formulations (placebo, cannabidiol, arnica, or a combination of cannabidiol and arnica) to explore whether these products modify the exercise response. The primary outcome is change in knee pain intensity measured using a visual analog scale. Secondary outcomes include adherence and safety. This pilot study aims to assess the feasibility, safety, and preliminary effectiveness of this low-cost and easily accessible strategy to inform future larger clinical trials.
Trial Details
NCT Number NCT07445568
Lead Sponsor Universidad del Valle de México, Campus Cuernavaca
Conditions Older Adults (60 - 85 Years Old), OA Knee
Enrollment 50 participants
Start Date 2025-09-01
Primary Completion 2025-09-01 (estimated)
Study Completion 2025-11-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-03