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Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes

Study acronym: CAAD-PVC
StatusRecruiting
PhaseNot applicable
Started2026-03-31
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary endpoint reworded 1 of 1 changed
See other at-risk trials from Western Sydney Local Health District

Amendment history

2026-09-25
Recruitment opened
Primary endpoint(s) modified1 entry, revised
WasChange in premature ventricular complex burden
NowProportion of participants with ≥80% reduction in PVC burden
Enrollment increased: 40 → 50 participants
Premature ventricular complexes (PVCs) are extra, abnormal heart beats arising from the ventricles of the heart and are the most common ventricular arrhythmia. PVCs can be treated with medication or with a procedure called catheter ablation. It is not known which provides a better cure or provides better quality of life. The purpose of this research project is to study the best way to treat PVCs by comparing the use of medication to catheter ablation to assess which approach is better at reducing symptoms and improving quality of life.
Trial Details
NCT Number NCT07445334
Lead Sponsor Western Sydney Local Health District
Conditions Premature Ventricular Complexes, Premature Ventricular Contraction (PVC), Premature Ventricular Beats
Enrollment 50 participants
Start Date 2026-03-31
Primary Completion 2027-09-01 (estimated)
Study Completion 2028-03-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-24