IL-33, sST2, and CRP in Panic Disorder

Panic disorder (PD) is characterized by recurrent and unexpected panic attacks and is associated with significant functional impairment. Increasing evidence suggests involvement of immune-inflammatory mechanisms in PD. Elevated levels of inflammatory markers such as C-reactive protein (CRP) have been reported in PD; however, interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), components of the IL-33/sST2 signaling axis, have not previously been investigated in PD. This cross-sectional case-control study aims to compare peripheral serum IL-33, sST2, and CRP levels between drug-naïve subjects diagnosed with PD and healthy controls (HCs). The findings may contribute to understanding the inflammatory mechanisms underlying PD.

NCT Number	NCT07444879
Lead Sponsor	Elazığ Mental Health and Diseases Hospital
Conditions	Panic Disorder
Enrollment	80 participants
Start Date	2025-07-07
Primary Completion	2026-03-23 (estimated)
Study Completion	2026-03-23 (estimated)
Updated on ClinicalTrials.gov	2026-03-04