Clinical Trial

10-Year Survival After Acute Hip Fracture in Patients With Preclinical/Clinical Alzheimer Pathology

Completed
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Summary
This study is a 10-year follow-up of a previously enrolled cohort of patients who underwent surgery for acute hip fracture with spinal anesthesia and had pre-fracture cognitive status assessed (Clinical Dementia Rating, CDR) and cerebrospinal fluid (CSF) biomarkers related to Alzheimer's disease measured (e.g., Aβ42/Aβ40 ratio, total tau, phosphorylated tau). The primary aim is to determine long-term survival at 10 years after index hip fracture surgery and to evaluate whether baseline cognitive status and/or Alzheimer-type CSF biomarker profiles are associated with long-term mortality.
Trial Details
NCT Number NCT07443566
Lead Sponsor Bengt Nellgård
Conditions Hip Fractures (ICD-10 72.01-72.2), Alzheimer s Disease, Dementia
Enrollment 404 participants
Start Date 2013-10
Primary Completion 2015-06 (estimated)
Study Completion 2015-06 (estimated)
Updated on ClinicalTrials.gov 2026-03-02