Evaluation of the Effects of Pulsed Electromagnetic Field on Inflammatory Knee Osteoarthritis

This study will assess the efficacy of pulsed electromagnetic field therapy in patients with inflammatory knee osteoarthritis confirmed by MRI-detected effusion-synovitis. Fifty participants will be randomly allocated into two groups. One group will receive active PEMF therapy at a specific optimized parameter twice a week for 8 weeks, while the other group will receive sham treatment using the same device without PEMF signal. The primary outcome is the change in WOMAC pain score, and secondary outcomes include knee function, stiffness, quality of life, and MRI-quantified structural changes.

NCT Number	NCT07443462
Lead Sponsor	The Hong Kong Polytechnic University Collaborators: Chinese University of Hong Kong, Zhujiang Hospital
Conditions	Knee Osteoarthritis (Knee OA)
Enrollment	50 participants
Start Date	2026-02-15
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-02