Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery

This study evaluates the dose-response relationship of Dexmedetomidine (DEX) in reducing the incidence and severity of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in elderly patients. The study compares different doses of DEX against a fentanyl control group in patients undergoing major lower limb orthopedic surgery under general anesthesia to determine the optimal dosage for cognitive protection.

NCT Number	NCT07443085
Lead Sponsor	Benha University
Conditions	Delirium - Postoperative
Enrollment	75 participants
Start Date	2026-02-26
Primary Completion	2027-07 (estimated)
Study Completion	2027-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-02