Clinical Outcomes and Complications in Two-stage Breast Reconstruction Using Microtextured and Nanotextured Expanders

This retrospective observational study evaluates clinical outcomes and complication rates in women who underwent two-staged implant-based breast reconstruction using tissue expanders and implants following mastectomy for breast cancer. The study focuses on comparing postoperative complications associated with nano- and microtextured tissue expanders and assessing the influence of prior radiotherapy on reconstructive outcomes. The hypothesis of the study is that the surface characteristics of tissue expanders and a history of radiotherapy may influence the incidence and type of postoperative complications as well as overall reconstructive success.

NCT Number	NCT07442838
Lead Sponsor	Comenius University
Conditions	Breast Neoplasms
Enrollment	88 participants
Start Date	2025-06-24
Primary Completion	2026-02-02 (estimated)
Study Completion	2026-04-28 (estimated)
Updated on ClinicalTrials.gov	2026-03-03