Perioperative Sepsis. An Epigenetic Perspective

This single-center, prospective, observational study evaluates the impact of perioperative sepsis on inflammatory response, coagulation abnormalities, cardiac dysfunction, and microRNA expression in adult patients undergoing major abdominal surgery. Forty patients are enrolled and classified into septic and non-septic groups according to international sepsis definitions based on SOFA score criteria. Clinical, biochemical, echocardiographic, and molecular parameters, including selected microRNAs, are assessed preoperatively and within the first 24 hours postoperatively. The study aims to characterize pathophysiological differences associated with perioperative sepsis and to explore the potential prognostic value of microRNAs as early biomarkers of postoperative sepsis.

NCT Number	NCT07442552
Lead Sponsor	Carol Davila University of Medicine and Pharmacy
Conditions	Sepsis Abdominal
Enrollment	40 participants
Start Date	2026-01-20
Primary Completion	2026-03-30 (estimated)
Study Completion	2026-04-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-02