Peripheral Nerve Blocks and Postoperative Pain and Mobilization After Total Knee Arthroplasty

Total knee arthroplasty (TKA) is frequently associated with significant postoperative pain, which may delay early mobilization and negatively affect functional recovery. Peripheral nerve blocks are widely used as part of multimodal analgesia strategies to improve postoperative pain control while minimizing opioid consumption and preserving motor function. Different peripheral nerve block techniques may result in varying analgesic efficacy and mobilization outcomes. The aim of this prospective observational study is to compare the effects of commonly used peripheral nerve block techniques on postoperative pain control and early mobilization in patients undergoing total knee arthroplasty under spinal anesthesia. Patients receiving fascia iliaca plane block are compared with those receiving a combination of adductor canal block and interspace between the popliteal artery and capsule of the knee (IPACK) block. The primary outcome is postoperative opioid consumption within the first 24 hours after surgery. Secondary outcomes include postoperative pain scores assessed at predefined time intervals, early mobilization parameters, and opioid-related adverse effects. The findings of this study are intended to contribute to optimizing analgesic strategies and improving early functional recovery following total knee arthroplasty.

NCT Number	NCT07442123
Lead Sponsor	Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Conditions	Arthropathy of Knee, Early Ambulation, Pain, Postoperative, Pain Management
Enrollment	90 participants
Start Date	2022-12-01
Primary Completion	2024-12-01 (estimated)
Study Completion	2025-01-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-03