Perioperative Multimodal Analgesia for Supratentorial Craniotomy

This randomized clinical trial aims to evaluate the effectiveness of scalp nerve blocks and dexmedetomidine in reducing opioid use and preventing postoperative delirium in patients undergoing supratentorial brain tumor surgery. A total of 2000 patients will be randomly assigned to one of four groups, receiving either active treatments, placebos, or their combinations. The main outcome measured will be the amount of opioid pain medication needed after surgery.

NCT Number	NCT07441421
Lead Sponsor	Beijing Tiantan Hospital
Conditions	Postoperative Pain, Analgesia, Supratentorial Brain Tumor
Enrollment	2,000 participants
Start Date	2026-03-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-02