Aspergillus Infection in Patients Admitted to Hematology Ward

Aspergillus is a filamentous mould ubiquitous in the environment and the concentration of its spores in the air varies according to weather conditions and seasons. In this regard, efforts are often made to limit its diffusion in wards where fragile patients are housed (e.g., ICU, Haematology, Oncology, etc.). Indeed, in these patients, Aspergillus infections can present as pulmonary aspergillosis, invasive rhinosinusitis or angio-invasive aspergillosis with significantly high rates of morbidity and mortality, while it rarely causes disease in healthy immunocompetent subjects. Previous studies have established the correlation between nasal carriage of microorganisms and the development of an invasive infectious disease; however, those studies mainly focused on Staphylococci and Candida species. The main target of this study is to investigate the spread of Aspergillus within a hospital ward and analyse the correlation between nosocomial infection and symptom severity in a cohort of frail population.

NCT Number	NCT07440485
Lead Sponsor	Fondazione IRCCS Policlinico San Matteo di Pavia
Conditions	Aspergillus Infection
Enrollment	193 participants
Start Date	2024-02-14
Primary Completion	2026-03-14 (estimated)
Study Completion	2026-03-14 (estimated)
Updated on ClinicalTrials.gov	2026-02-27