Promoting Neuroplastic Mechanisms With Modeling-based Optimization of a Novel Robot-asisted Walking Rehabilitation Therapy

The goal of this observational study is to assess the course of motor and functional gait recovery induced by Lokomat robot-assisted gait rehabilitation in patients with spinal cord injury. The main question it aims to answer is: How does gait motor and functional multilevel recovery progress over time in patients with spinal cord injury? Assessmets will be conducted at four time points: pre-intervention, mid-intervention, post-intervention, and at 1-month follow-up after the completion of robot-assisted gait rehabilitation. Data will be collected at multiple levels, including: * Clinical tests * Three-dimensional gait analysis with kinematic, kinetic, and electromyographic measurements * Maximum isometric strength * Nerve conduction parameters

NCT Number	NCT07440459
Lead Sponsor	BioRobotics Group - Spanish National Research Council (CSIC) Collaborators: Spanish National Research Council, Castilla-La Mancha Health Service, Hospital Nacional de Parapléjicos de Toledo
Conditions	Spinal Cord Injuries (SCI), Spinal Cord Injury, Neurorehabilitation, Robot Assisted Gait Training
Enrollment	10 participants
Start Date	2023-06-12
Primary Completion	2024-06-19 (estimated)
Study Completion	2024-11-29 (estimated)
Updated on ClinicalTrials.gov	2026-02-27