Clinical Trial

Investigation of Protein Heterogeneity in Extracellular Vesicles Derived From Different Human Blood Circulatory Regions

Study acronym: DBCR-EV-p
Recruiting
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Record status
This record was last updated February 27, 2026 (before its estimated April 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this observational study is to learn about the protein heterogeneity in extracellular vesicles (EVs) derived from different human blood circulatory regions of patients with ruptured or unruptured intracranial aneurysms. The main objectives are: Reveal the proteomic heterogeneity of EVs in different blood circulatory regions of the human body。 Reveal the proteomic differences of EVs in cerebral feeding arteries and draining veins between patients with aneurysmal subarachnoid hemorrhage and those without hemorrhage. Explore EV-derived protein biomarkers that reflect the diagnosis and prognosis of subarachnoid hemorrhage
Trial Details
NCT Number NCT07439965
Lead Sponsor The First Hospital of Jilin University
Conditions Subarachnoid Aneurysm Hemorrhage, Unruptured Intracranial Aneurysm
Enrollment 120 participants
Start Date 2025-07-29
Primary Completion 2026-04 (estimated)
Study Completion 2026-06 (estimated)
Updated on ClinicalTrials.gov 2026-02-27