Simplified Dual Regimen Guided by Fecal Clarithromycin Resistance Gene Detection for First-line H. Pylori Eradication

To investigate the efficacy, safety, and compliance of a simplified strategy using vonoprazan plus clarithromycin for first-line treatment in patients with Helicobacter pylori infection, among those infected with strains without clarithromycin resistance gene mutations based on fecal clarithromycin resistance gene detection.

NCT Number	NCT07439445
Lead Sponsor	Peking University First Hospital
Conditions	Helicobacter Pylori Infection
Enrollment	70 participants
Start Date	2026-04-25
Primary Completion	2027-02-13 (estimated)
Study Completion	2027-02-13 (estimated)
Updated on ClinicalTrials.gov	2026-04-30