Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.

Better treatments are needed for high-grade gliomas (HGG), and new ways of treating this disease should be tested. The investigators want to see if giving medicine before radiation works well. After radiation, MRI scans can be harder to understand because radiation changes how the brain looks on the scan. If new medicines are given before radiation, the scans are easier to read. First, the investigators need to find out if giving chemotherapy early works using a drug we already know can treat gliomas. The investigators will start with temozolomide, which is the only chemotherapy approved by the FDA for HGG. If this approach is successful, the investigators can then test new drugs using this screening method.

NCT Number	NCT07439172
Lead Sponsor	The Cooper Health System Collaborators: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, University of Virginia, Virginia Commonwealth University, Wake Forest University, Georgetown University, Musella Foundation, Imaging Biometrics, LLC, West Virginia University
Conditions	High Grade Gliomas, Glioblastoma, Astrocytoma, Oligodendroglioma
Enrollment	70 participants
Start Date	2026-03
Primary Completion	2028-09 (estimated)
Study Completion	2029-09 (estimated)
Updated on ClinicalTrials.gov	2026-02-27