Clinical Trial

Effect of Mediterranean vs Paleolithic Diet on RA Activity, Sarcopenia and QOL: 12-Week RCT

Recruiting
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Record status
This record was last updated February 27, 2026 (before its estimated June 15, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study aims to evaluate the effects of Mediterranean and Paleolithic dietary interventions on nutritional status, disease activity, fatigue, sleep, and quality of life in adults with rheumatoid arthritis (RA). Participants aged 40-60 years will be randomly assigned to follow either a Mediterranean diet, a Paleolithic diet, or continue their usual diet for 12 weeks. The study will assess anthropometric measurements, disease activity score (DAS28), laboratory biomarkers (CBC, CRP, ESR, lipid profile, fasting glucose, HbA1c), and patient-reported outcomes. The trial will determine whether these diets improve RA management and overall well-being.
Trial Details
NCT Number NCT07438652
Lead Sponsor Kasr El Aini Hospital
Conditions Rheumatoid Arthritis (RA)
Enrollment 75 participants
Start Date 2026-01-17
Primary Completion 2026-06-15 (estimated)
Study Completion 2026-07-15 (estimated)
Updated on ClinicalTrials.gov 2026-02-27