Clinical Trial

Predictors of Decompensation, Acute-on-chronic Liver Failure and Mortality in Liver Cirrhosis

Study acronym: SoLiDaRity
Recruiting
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Summary
The purpose of this study is to identify factors that predict the development of decompensation, acute-on-chronic liver failure (ACLF) and death in patients with liver cirrhosis. Clinical data will be retrieved from existing hospital records. This information may help doctors to identify patients with cirrhosis who are at risk of deterioration earlier (before they develop complications) and to develop effective treatment strategies to prevent or delay these complications. This study is designed as a prospective, non-interventional, observational study. This means that if you agree to participate in the study, you will not be required to undergo any additional hospital visits, tests, procedures or interventions other than the usual standard-of-care management that your doctor will provide. If you consent to participate in this study, you will be providing the study investigators permission to review and analyse your clinical data from the hospital clinical records. Your data will be collected throughout the course of your disease until liver transplantation or death.
Trial Details
NCT Number NCT07438288
Lead Sponsor Singapore General Hospital
Conditions Cirrhosis and Chronic Liver Disease
Enrollment 2,200 participants
Start Date 2022-08-12
Primary Completion 2027-08-12 (estimated)
Study Completion 2032-08-12 (estimated)
Updated on ClinicalTrials.gov 2026-02-27