Periodontal Therapy and Genitourinary Inflammation in Patients With Prostatitis and Recurrent Urinary Tract Infections

This randomized controlled clinical trial evaluates the impact of non-surgical periodontal therapy on systemic inflammatory markers in patients with chronic prostatitis or recurrent urinary tract infections. Emerging evidence suggests a possible association between periodontal inflammation and genitourinary conditions. A total of 60 male participants diagnosed with periodontitis and either chronic prostatitis or recurrent urinary tract infections were randomly assigned to one of three groups: non-surgical periodontal therapy, oral hygiene instruction only, or no periodontal treatment. The primary outcomes were changes in serum prostate-specific antigen (PSA) levels and the frequency of positive urine cultures over a 120-day follow-up period. The study aims to investigate whether periodontal treatment may reduce systemic inflammatory burden and improve genitourinary clinical parameters.

NCT Number	NCT07438184
Lead Sponsor	University of Salamanca
Conditions	Periodontitis, Chronic Prostatitis (CP), Urinary Tract Infections
Enrollment	60 participants
Start Date	2024-01-01
Primary Completion	2025-04-01 (estimated)
Study Completion	2025-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-13