Clinical Trial

EBV-AST Cell Therapy for EBV-Related Diseases After Stem Cell Transplantation

Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
This exploratory clinical study focuses on the use of EBV-AST cell infusion for treating EBV-DNA viremia following allogeneic hematopoietic stem cell transplantation (Allo-HSCT). The study aims to determine the maximum tolerated dose (MTD) or optimal biological dose (OBD) of EBV-AST cells and assess their safety, tolerability, and preliminary efficacy in treating EBV-DNA viremia. The study will involve a 3+3 dose escalation design to evaluate three different dosages of EBV-AST cell infusion. The study is expected to provide important insights into the clinical application of cell-based therapies for EBV infections.
Protocol Amendment History 1 change
critical Phase changed: Phase 1/2 -> Phase 1 2026-08-07
Trial Details
NCT Number NCT07438067
Lead Sponsor Daihong Liu
Conditions EBV-DNA Viremia
Enrollment 18 participants
Start Date 2025-03-26
Primary Completion 2028-03-26 (estimated)
Study Completion 2028-03-26 (estimated)
Updated on ClinicalTrials.gov 2026-08-06