Clinical Trial

A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With or Without Comorbid Asthma

Recruiting Phase 1/2
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Summary
This study is a randomized, double-Blind, placebo-controlled, Single and Multiple-ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Participants with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) with or without Asthma.
Protocol Amendment History 3 changes
critical Recruitment opened 2026-07-23
notable Primary completion pushed: 2026-12-31 -> 2027-12-31 2026-07-23
minor Completion pushed: 2027-05-30 -> 2028-06-30 2026-07-23
Trial Details
NCT Number NCT07436949
Lead Sponsor Bambusa Therapeutics
Conditions Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Enrollment 64 participants
Start Date 2026-03-02
Primary Completion 2027-12-31 (estimated)
Study Completion 2028-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-22