Clinical Trial

Iron Absorption From IFA and MMS Supplements in Kenyan Women During the Second Trimester of Pregnancy

Study acronym: PROUD
Recruiting
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Record status
This record was last updated February 27, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study evaluates iron absorption from three antenatal supplements, 30 mg MMS, 60 mg MMS, and 60 mg IFA, in 50 pregnant Kenyan women in their second trimester. Using a randomized crossover design and stable iron isotopes, we will compare bioavailability in both fasted and fed states. Additionally, the trial will investigate if daily dosing triggers a hepcidin response that inhibits subsequent absorption, testing whether alternate-day dosing is a more effective strategy for treating iron deficiency.
Trial Details
NCT Number NCT07435766
Lead Sponsor ETH Zurich
Conditions Pregnancy
Enrollment 50 participants
Start Date 2026-03-02
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-27