Adding Magnesium Sulfate to Combined Pecto-Intercostal & Serratus Anterior Planes Block on Post-operative Analgesia in Patients Undergoing Modified Radical Mastectomy

Here, in our study, we intend to compare the analgesic efficacy of magnesium sulfate as an adjuvant to local anesthetics added to the Pecto-Intercostal Fascial Block (PIFB) vs the Serratus Anterior Plane Block (SAPB) in patients undergoing modified radical mastectomy. Study Endpoints Primary Endpoints: Total intravenous opioid consumption during the first 24 hours following surgery. Secondary Endpoints: Postoperative analgesia, 24 hours after surgery, assessed using the Visual Analog Scale (VAS) and time to first analgesic request.

NCT Number	NCT07434232
Lead Sponsor	South Egypt Cancer Institute Collaborators: Assiut University
Conditions	Modified Radical Mastectomy
Enrollment	100 participants
Start Date	2026-02-15
Primary Completion	2026-12-01 (estimated)
Study Completion	2027-04-15 (estimated)
Updated on ClinicalTrials.gov	2026-02-25