Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers

The goal of this clinical trial is to compare post-treatment pain after root canal therapy in adults with irreversible pulpitis using different root canal sealers. The study will also evaluate the need for pain medication after treatment. The main questions this study aims to answer are: Does the type of root canal sealer affect the intensity of pain after treatment? Does the type of sealer influence the number of analgesic tablets taken by participants? How does pain change over time after treatment with different sealers? Researchers will compare two bioceramic sealers (EndoSeal TCS and NeoSeal) with a resin-based sealer (AH Plus) to determine their effects on post-endodontic pain. Participants will: Receive root canal treatment using one of the study sealers Report their pain intensity at specific time points after treatment Record the number of analgesic tablets taken during the follow-up period

NCT Number	NCT07434141
Lead Sponsor	Tehran University of Medical Sciences
Conditions	Symptomatic Irreversible Pulpitis (SIP), Symptomatic Irreversible Pulpitis With Apical Peridontitis
Enrollment	75 participants
Start Date	2025-06-08
Primary Completion	2026-04 (estimated)
Study Completion	2026-05-30 (estimated)
Updated on ClinicalTrials.gov	2026-02-25