Clinical Trial

CT Body Composition as Predictor of Exercise Therapy Outcome in Peripheral Arterial Disease

Study acronym: COMPOSE-PAD
Not Yet Recruiting
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Summary
Supervised exercise therapy (SET) is the recommended first treatment for patients with leg artery disease (peripheral arterial disease, PAD) causing pain when walking. However, approximately 40% of patients do not benefit meaningfully and go on to require a procedure to open the blocked arteries within three months. This study investigates whether body composition measurements - specifically the quality of muscle and the amount of belly fat - taken from a CT scan already performed as part of routine care, can identify before treatment begins which patients are unlikely to respond to exercise therapy. If confirmed, this approach would allow doctors to use information from a scan patients are already having, with no additional tests, to better match patients to the right treatment from the start.
Trial Details
NCT Number NCT07433309
Lead Sponsor Nemocnice AGEL Trinec-Podlesi a.s.
Conditions Sarcopenia, Body Composition, Sarcopenic Obesity, Peripheral Arterial Disease
Enrollment 128 participants
Start Date 2026-06-01
Primary Completion 2030-12-31 (estimated)
Study Completion 2031-01-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-25