Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches

This is a national, observational, retrospective, cross-sectional, non-profit study focused on patients with HCC. The study aims to characterize the expression and function of novel noncoding regulatory transcripts, including those containing TEsin the microenvironment of liver tumors, with emphasis on their role in T cell dysfunction.

NCT Number	NCT07432347
Lead Sponsor	Niguarda Hospital Collaborators: San Raffaele University Hospital, Italy, Fondazione Istituto Nazionale Genetica Molecolare - INGM, University of Milan
Conditions	Hepatocarcinoma
Enrollment	270 participants
Start Date	2026-01-01
Primary Completion	2029-01-31 (estimated)
Study Completion	2031-01-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-27