Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection

Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia. The SILENCE-NEUROMA Trial is a multicenter, randomized, double-blind, active-controlled study designed to compare the efficacy and safety of botulinum toxin type A versus local anesthetic injection for the treatment of neuroma-related pain. The primary outcome is pain reduction at 8 weeks after treatment.

NCT Number	NCT07431944
Lead Sponsor	Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Conditions	Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
Enrollment	100 participants
Start Date	2026-02-15
Primary Completion	2026-02-15 (estimated)
Study Completion	2026-12-15 (estimated)
Updated on ClinicalTrials.gov	2026-02-25