Safety and Efficacy of J147 in Acute Ischemic Stroke

The goal of this clinical trial is to find out if the drug J147 improves outcomes for persons who have had an ischemic stroke. It also will learn about the safety of J147 when given by injection to stroke patients. Researchers will compare the outcomes of those who receive J147 after therapy to clear the blood clot to those who don't receive J147. Participants will be asked to undergo a series of three to four magnetic resonance imaging (MRI) brain scans, and blood samples will be collected at several time points. Participants will also be evaluated to measure several aspects of brain function.

NCT Number	NCT07430917
Lead Sponsor	Abrexa Pharmaceuticals, Inc. Collaborators: IQVIA RDS Inc.
Conditions	Acute Ischemic Stroke
Enrollment	196 participants
Start Date	2026-04-20
Primary Completion	2028-03-01 (estimated)
Study Completion	2028-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-07