Metabolic Flexibility and Ketone Production During Energy Deficit

This randomized, interventional study examines the effects of short-term carbohydrate restriction, with and without caloric restriction, on indices of metabolic flexibility in healthy adults. Participants are randomly assigned to either a low-carbohydrate diet or a standard diet under energy balance, followed by the same diet under controlled caloric restriction. Primary outcomes include measures of carbon dioxide production, breath ketones and interstitial glucose. Secondary outcomes include blood and urinary ketones, body weight, body composition, and selected metabolic biomarkers.

NCT Number	NCT07429058
Lead Sponsor	Technical University of Munich Collaborators: Metaflow Ltd.
Conditions	Dietary Carbohydrate Restriction, Energy Deficit
Enrollment	30 participants
Start Date	2023-11-24
Primary Completion	2024-03-11 (estimated)
Study Completion	2024-04-26 (estimated)
Updated on ClinicalTrials.gov	2026-02-24