Sex Differences in Exercise-Induced Hypoalgesia

Exercise-induced hypoalgesia (EIH) refers to the reduction in pain sensitivity following acute exercise. Although aerobic exercise has been shown to induce hypoalgesia in healthy individuals, it remains unclear whether the magnitude of this response differs between men and women. This quasi-experimental study aims to evaluate sex differences in pressure pain thresholds following a standardized aerobic exercise protocol using a lower-limb cycle ergometer. Pressure pain thresholds will be assessed before exercise, immediately after exercise, and 30 minutes after exercise in healthy adults aged 18 to 65 years. The findings of this study may contribute to improving individualized exercise prescription strategies based on sex differences in pain modulation.

NCT Number	NCT07427979
Lead Sponsor	Centro Universitario La Salle Collaborators: Universidad Rey Juan Carlos
Conditions	Healthy Adult
Enrollment	30 participants
Start Date	2026-03-15
Primary Completion	2026-05-15 (estimated)
Study Completion	2026-07-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-18