Clinical Trial

Cognitive Rehabilitation With Immersive Virtual Reality (IVR) in Schizophrenia: a Pilot Randomized Waiting List Controlled Feasibility Study

Study acronym: IVR SCZ

Completed

Summary

Virtual reality-based rehabilitation has recently gained increasing attention in the field of cognitive rehabilitation, allowing patients to engage in simulated real-life scenarios within a safe and controlled setting. The feasibility and safety of immersive VR-based cognitive rehabilitation in individuals with schizophrenia is currently insufficiently explored. This study seeks to evaluate whether immersive immersive virtual reality-based rehabilitation can be safely and practically implemented in a community psychiatric setting. The study also aims to explore preliminary effects on negative symptoms, cognitive performance, and global functioning compared with treatment as usual in a waiting-list control group.

Protocol Amendment History 2 changes

critical Trial completed 2026-06-16

notable Primary completion pushed: 2026-02 -> 2026-03-11 2026-06-16

Trial Details

NCT Number	NCT07427485
Lead Sponsor	Azienda Sanitaria Locale Napoli 3 Sud, UOCSM Torre del Greco
Conditions	SCHIZOPHRENIA 1 (Disorder), Schizoaffective Disorder
Enrollment	40 participants
Start Date	2025-03-11
Primary Completion	2026-03-11 (estimated)
Study Completion	2026-03-11 (estimated)
Updated on ClinicalTrials.gov	2026-06-15