African Studies on Aging and Noncommunicable Diseases Epidemiology

Despite the rising burden of noncommunicable diseases (NCDs), including cardiovascular diseases (CVDs), across Africa, high-quality evidence on the distribution of NCDs and their risk factors remains strikingly scarce. Many global estimates continue to rely on limited empirical data from African countries, and this persistent data gap has led major international research collaborations to underrepresent the continent. This reality highlights an urgent need for granular, context-specific, and methodologically robust data on NCDs and their determinants across Africa. The African Studies on Ageing and Noncommunicable Disease Epidemiology (ASANDE) initiative responds directly to this need by assembling harmonized, individual-level datasets from African populations, complemented by comparable data from other global regions. With recruitment underway, ASANDE seeks to quantify and compare the associations between major NCD risk factors, including cardiometabolic, behavioral, and environmental determinants, and the incidence and mortality of major NCD outcomes (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, and other NCDs) across world regions, with a particular emphasis on disparities between African populations and the rest of the global population.

NCT Number	NCT07427355
Lead Sponsor	Alliance For Medical Research in Africa Collaborators: Institut Pasteur de Dakar
Conditions	Cardio Vascular Disease, Cardiovascular, Cancer, Mortality
Enrollment	1,000,000 participants
Start Date	2025-01-15
Primary Completion	2026-07 (estimated)
Study Completion	2030-06 (estimated)
Updated on ClinicalTrials.gov	2026-02-23