Virtual Reality-assisted Cognitive Rehabilitation in Autistic Youth With ADHD

This study aims to evaluate the effectiveness of a virtual reality-based intervention using the Virtual Reality Rehabilitation System (VRRS) to improve executive functions in autistic and ADHD youth aged 8 to 18 years. Executive functions, such as working memory, cognitive flexibility, and inhibitory control, are frequently impaired in individuals with autism and/or ADHD and significantly affect daily functioning. Participants will be randomly assigned to either an experimental group that receives VRRS-assisted cognitive training or a control group that receives treatment as usual. The intervention includes gamified tasks within immersive virtual environments specifically designed to stimulate executive skills. The primary outcome is the change in executive function scores from baseline to post-intervention, assessed using validated neuropsychological instruments. The study adopts a randomized controlled design.

NCT Number	NCT07426302
Lead Sponsor	IRCCS Centro Neurolesi Bonino Pulejo
Conditions	ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder
Enrollment	50 participants
Start Date	2023-06-01
Primary Completion	2026-06-30 (estimated)
Study Completion	2026-07 (estimated)
Updated on ClinicalTrials.gov	2026-02-23