Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration

Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?

NCT Number	NCT07426016
Lead Sponsor	University of Texas Southwestern Medical Center
Conditions	Respiratory Distress Syndrome (Neonatal), Surfactant Deficiency Syndrome Neonatal
Enrollment	100 participants
Start Date	2026-06-11
Primary Completion	2028-06 (estimated)
Study Completion	2028-11 (estimated)
Updated on ClinicalTrials.gov	2026-06-15