Venetoclax Combined With Azacitidine for Consolidation Therapy in AML

The goal of this clinical trial is to compare the efficacy and safety of a venetoclax-based consolidation therapy versus conventional consolidation chemotherapy in newly diagnosed adult patients with high-risk acute myeloid leukemia (AML) who have achieved complete remission (CR) or CR with incomplete hematologic recovery (CRi) after induction therapy with venetoclax and azacitidine and are planned for transplantation. The main questions it aims to answer are: Does consolidation therapy with a venetoclax-containing regimen lead to superior clinical outcomes compared to conventional chemotherapy in this specific patient population? What is the comparative safety profile of the venetoclax-containing consolidation regimen versus conventional chemotherapy in these patients? Participants will be randomly assigned to receive either the venetoclax-based consolidation therapy or the conventional consolidation chemotherapy before undergoing transplantation.

NCT Number	NCT07425782
Lead Sponsor	The First Affiliated Hospital of Soochow University
Conditions	Acute Myeloid Leukemia, Consolidation Therapy, Venentoclax, High Risk, Hematopoietic Stem Cell Transplant (HSCT)
Enrollment	216 participants
Start Date	2026-02-01
Primary Completion	2028-11-26 (estimated)
Study Completion	2028-11-26 (estimated)
Updated on ClinicalTrials.gov	2026-08-06