Clinical Trial

HELIOS Advanced: Human Oocyte Illumination to Enhance Development

Study acronym: HELIOS-A

Recruiting

Summary

Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for eggs and embryos to develop normally. One possible way to help is with a gentle light treatment called photobiomodulation (PBM). This uses a special type of red light that boosts energy production in cells and helps them stay healthy. This study will test whether adding this light treatment during in vitro fertilization (IVF) can improve embryo growth and pregnancy outcomes.

Protocol Amendment History 1 amendment

This ClinicalTrials.gov record has been amended once since 2026-02-13.

Status change: Not Yet Recruiting → Recruiting 2026-03-23

Trial Details

NCT Number	NCT07425080
Lead Sponsor	Columbia University
Conditions	IVF Outcomes
Enrollment	270 participants
Start Date	2026-03-24
Primary Completion	2027-06-01 (estimated)
Study Completion	2028-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-25