Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)

The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement. The primary question is whether EUS-PPG provides measurements really equivalent to HVPG in terms of gradient accuracy. Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.

NCT Number	NCT07424963
Lead Sponsor	Military University Hospital, Prague Collaborators: Institute for Clinical and Experimental Medicine
Conditions	Cirrhosis, Portal Hypertension, EUS, Non-Cirrhotic Portal Hypertension, HVPG, Hepatic Venous Pressure Gradient
Enrollment	40 participants
Start Date	2025-05-30
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-20