Clinical Trial

Fluoxetine on Emotional Experience (FLEX) Study

Study acronym: FLEX
Recruiting
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Summary
The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people . The main questions it aims is to answer are: 1. How does fluoxetine affect responses to anger-related stimuli such as words, faces, and autobiographical recall? 2. How does fluoxetine influence responses during frustration induction in frustrative non-reward and threat paradigms? 3. Does the effect manifest in physiological markers, including heart rate variability and facial expressions? Researchers will compare fluoxetine to a placebo to see if drug fluoxetine affects anger processing. Participants will: Take 20mg fluoxetine or a placebo every day for 7 days. Visit the university site for questionnaire and tasks assessments. Heart rate variability and facial expressions will be recorded in some of the tasks.
Trial Details
NCT Number NCT07424781
Lead Sponsor University of Oxford
Collaborators: Wellcome Trust, National Institute for Health Research, United Kingdom
Conditions Depression - Major Depressive Disorder, Irritability, Depression
Enrollment 80 participants
Start Date 2025-10-01
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-20